Evaluating the Potentiating Effect of Galbanic acid from Ferula szowitsiana on three common antibiotics against resistant hospital isolates of Staphylococcus aureus

نویسندگان

  • AR Du
  • BS Fazly Bazzaz
  • M Iranshahi
  • M Khajeh Karamodin
  • M Naderinasab
چکیده مقاله:

The plant kingdom constitutes a source of new chemical compounds, which may be important due to their potential uses in medicine, or their other biological properties. In this study, the effects of Galbanic acid (GA), a sesquiterpene coumarin from roots of Ferula szowitsiana, were investigated as a modulator of antibiotic resistance in clinical isolates of Staphylococcus aureus. Isolates of S. aureus clinically resistant to methicillin, tetracycline and ciprofloxacin were isolated using disk diffusion method. The MICs of antibiotics were determined using broth macrotiter plate method against isolated bacteria. The inhibitory effects of GA alone and in combination with each antibiotic were investigated by macrotiter plate. None of the tested bacteria were affected by GA (up to 800 µg/mL). MICs of antibiotics against S. aureus (in µg/mL) were 10-80 for methicillin, 40->80 for tetracycline, and10-20 for ciprofloxacin. The MICs of antibiotics in presence of 400 µg/mL GA were less than 1.25 µg/mL for S. aureus, which is usually much less than the MICs against sensitive isolates. This study provides interesting results suggesting a potentiating activity of GA on antibiotics against the resistant strains of S. aureus.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

evaluating the potentiating effect of galbanic acid from ferula szowitsiana on three common antibiotics against resistant hospital isolates of staphylococcus aureus

the plant kingdom constitutes a source of new chemical compounds, which may be important due to their potential uses in medicine, or their other biological properties. in this study, the effects of galbanic acid (ga), a sesquiterpene coumarin from roots of ferula szowitsiana, were investigated as a modulator of antibiotic resistance in clinical isolates of staphylococcus aureus. isolates of s. ...

متن کامل

Effect Of Galbanic Acid, A Sesquiterpene Coumarin From Ferula Szowitsiana, As An Inhibitor Of Efflux Mechanism In Resistant Clinical Isolates Of Staphylococcus Aureus

Galbanic acid, a sesquiterpene coumarin from Ferula szowitsiana roots, was investigated for its potentiating effect on the antimicrobial activity of antibiotics as well as ethidium bromide, in 6 multidrug resistance (MDR) clinical isolates of Staphylococcus aureus. Galbanic acid had inhibitory effect on none of the isolated bacteria tested (up to 800 μg /ml). The MIC range of ciprofloxacin, tet...

متن کامل

Evaluation and comparison of antimicrobial effect of graphene oxide and common antibiotics on standard and hospital Resistant Staphylococcus aureus

Background: Graphene chips are insoluble forms of graphene. Graphene is highly reactive and has no biocompatibility, but after oxidation, it becomes water-soluble. Graphene oxide (GO) is applied in biomedical, including gene and drug transfer, biomedical imaging, biomedical sensors, and antibiotics. Staphylococcus aureus is a gram-positive bacteria and is the most important species in Staphyloc...

متن کامل

the effect of traffic density on the accident externality from driving the case study of tehran

در این پژوهش به بررسی اثر افزایش ترافیک بر روی تعداد تصادفات پرداخته شده است. به این منظور 30 تقاطع در شهر تهران بطور تصادفی انتخاب گردید و تعداد تصادفات ماهیانه در این تقاطعات در طول سالهای 89-90 از سازمان کنترل ترافیک شهر تهران استخراج گردید و با استفاده از مدل داده های تابلویی و نرم افزار eviews مدل خطی و درجه دوم تخمین زده شد و در نهایت این نتیجه حاصل شد که تقاطعات پر ترافیک تر تعداد تصادفا...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره Volume 8  شماره Number 3

صفحات  217- 221

تاریخ انتشار 2010-11-20

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023